Male bias in health research targeted by scientists

Network led by a St John’s biologist works to transform understanding of women’s medical research and care
Professor Amanda Sferruzzi-Perri

How is it possible that a woman is 50 per cent more likely to receive the wrong initial diagnosis for a heart attack than a man?  

Or that men who report pain to a doctor tend to be prescribed pain medication, but women are more likely to be given sedatives or antidepressants?

The historically male-dominated medical profession has driven a male bias in health research and care.  

Now a new network of experts at the University of Cambridge is trying to redress the balance.

“Research that wasn’t designed with women in mind has contributed to a healthcare system that doesn’t meet women’s needs,” said network leader Professor Amanda Sferruzzi-Perri, University Professor in Fetal and Placental Physiology in the Department of Physiology, Development and Neuroscience, and a Fellow of St John’s.

For centuries, many aspects of female biology were not discussed – and in some cultures this is still the case today. Women have been sidelined or excluded from research into health conditions and drug treatments, their fluctuating hormones thought to be too much of a complication to getting reliable results.

The result is an alarming lack of understanding of many women’s health conditions, the ways women experience illness and disease differently to men, and the differences in their response to treatments.

Professor Sferruzzi-Perri, who is College Lecturer in Physiology and Reproductive Biology, says the waves of hormonal changes that happen throughout a woman’s reproductive years, which don’t occur in men, affect the body’s immune system, metabolic system, and cardiovascular and respiratory systems.

“Puberty, pregnancy, breastfeeding and menopause can all permanently alter the female body and are associated with a range of female-specific health issues and benefits,” she said.  

“This leads to different rates of certain conditions in men and women, as well as differences in how these conditions are experienced. We can’t simply generalise medical treatment across the sexes.”

Members of the network working to vastly improve understanding of women’s health are academics across University Departments, including in mental health, breastfeeding, and archaeology.

Read the full feature, ‘Putting women’s health in the spotlight’, on the University of Cambridge website.

News
Research

Related articles

Leading thinkers discuss faith in a fractured society

Theologians, bishops, and practitioners gathered at St John’s to explore how Christian social thought can respond to growing social division and contribute to the common good

News
A portrait photo of Dr Rakesh Arul in The Cloisters of St Johns College, Cambridge
Molecules synchronising ‘like fireflies’ could lead to new quantum technologies

Physicists find way previously thought impossible to make molecules act together at room temperature – a discovery with potential for a range of future devices

News
Research
Physicist Dr Pratyush Ghosh crouches down in the laboratory to study an experiment
St John’s Research Fellows competition 2027 launches for early-career academics

Rare opportunity for up to four outstanding junior researchers to pursue independent post-doctoral work as part of St John's College, Cambridge’s welcoming interdisciplinary community

News
Research
A BBC panel show photo from University Challenge with presenter Amol Rajan in the middle of the contestants from St John's College
St John's students face Oxford in University Challenge

Cambridge contestants appear in the fiendishly difficult BBC quiz tournament that pits teams from higher education institutions across the UK against each other

News