SpecialisationStructural biology, Electron microscopy
Research interestsMany of the outstanding questions in biology and medicine are difficult to address because there is no way to directly look at the complex molecular machines responsible for life. I work on developing new instruments and methods for imaging biological molecules, (DNA, RNA and proteins), at atomic resolution. This is done by improving the resolving power and image quality of the electron microscope to the point where we can image the atomic structure of molecules. This requires reengineering how specimens are made and imaged, to prevent them from moving before they are damaged by the high-energy electrons in the microscope. Using this new technology, we study the detailed mechanisms of bimolecular complexes to understand how they function.