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Research led by Dr Tuomas Knowles identifies trigger for Alzheimer’s disease

Amyloid fibril, magnified a million times
Amyloid fibril, magnified a million times, the type of protein structures that are formed in Alzheimer’s. Credit: Dr Tuomas Knowles

A group of research scientists led by Dr Tuomas Knowles, a current Fellow of St John's College, have recently identified the molecular trigger for Alzheimer's disease.

The research, recently published in the Proceedings of the US National Academy of Sciences, maps the pathway that generates abnormal forms of protein which are the root cause of neurodegenerative conditions like Alzheimer's disease. It is hoped that new techniques for earlier diagnosis and improved treatment could be developed with this better understanding of the underlying molecular processes.

Professor Chris Dobson, Master of St John's, and Professor Michele Vendruscolo also lead the research, which was conducted in collaboration with Professor Sara Linse and colleagues at Lund University in Sweden.

Read the full article on the University of Cambridge Research website.